fda approved drug library (Selleck Chemicals)
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fda approved drug library
Fda Approved Drug Library, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 96/100, based on 436 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/fda+approved+drug+library/FDA-approved+Drug+Library/pmc13044278-313-15-18
Average 96 stars, based on 436 article reviews
Fda Approved Drug Library, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 96/100, based on 436 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/fda+approved+drug+library/FDA-approved+Drug+Library/pmc13044278-313-15-18
Average 96 stars, based on 436 article reviews
fda approved drug library - by Bioz Stars,
2026-09
96/100 stars
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1) Product Images from "Glucocorticoids elevate clear cell renal cell carcinoma sensitivity to HIF-2α inhibitors by suppressing H4K12 lactylation"
Article Title: Glucocorticoids elevate clear cell renal cell carcinoma sensitivity to HIF-2α inhibitors by suppressing H4K12 lactylation
Journal: Signal Transduction and Targeted Therapy
doi: 10.1038/s41392-026-02622-7
Figure Legend Snippet: Six GCs inhibited H4K12la in ccRCC cells. a Experimental workflow of high-content drug screening for the quantification of H4K12la in 786-O control cells. 786-O cells were seeded in 384-well plates and then treated with FDA-approved drugs ( n = 2468) for 48 h. 786-O cells treated with vehicle were used as controls. Immunofluorescence staining of 786-O cells with H4K12la antibody (green). DAPI staining was used to visualize the nucleus (blue). High-content analysis with automatic image processing was applied to determine the mean immunofluorescence intensity per cell. b The relative average fluorescence intensity (RAFI) of 786-O cells treated with FDA-approved drugs compared with the vehicle control group. The drugs that caused a significant decrease in the relative average immunofluorescence intensity of H4K12la compared with that of the control group are labeled in red. A 40% reduction in the RAFI was considered to indicate a remarkable decrease (RAFI < 0.6, n = 15). c The top 15 drugs in terms of average fluorescence intensity compared with the vehicle control group. Blue, control group; red, GCs. d Immunofluorescence staining of 786-O cells treated with vehicle or the indicated GCs (10 μM), including DEX, BEC, FLUD, FLUO, MOME, and PRED, for 48 h with H4K12la antibody (green). DAPI staining was used to visualize the nucleus (blue). Bar, 50 μm. e Western blot analysis of H4K12la and H3K18la in 786-O cells treated with vehicle or the indicated drugs (10 μM) for 48 h. f Western blot analysis of H4K12la and H3K18la in 786-O cells treated with vehicle or DEX at the indicated concentrations for 48 h
Techniques Used: Drug discovery, Control, Immunofluorescence, Staining, High Content Screening, Fluorescence, Labeling, Western Blot
Related Articles
Drug discovery:Article Title: High-throughput screening identifies a trafficking corrector for long QT syndrome–associated KCNQ1 variants Article Snippet: .. Small molecules from the following libraries were screened: (a) Article Title: Glucocorticoids elevate clear cell renal cell carcinoma sensitivity to HIF-2α inhibitors by suppressing H4K12 lactylation. Article Snippet: Antibodies and reagents The antibodies used were anti-L-Lactyl-Histone H3 (Lys14) (1: 2000), anti-L-Lactyl-Histone H3 (Lys18) (1: 2000), anti-L-LactylHistone H3 (Lys23) (1: 1000), anti-L-Lactyl-Histone H4 (Lys5) (1: Signal Transduction and Targeted Therapy (2026) 11:117 1000), anti-L-Lactyl-Histone H4 (Lys12) (1: 2000) (catalog number: PTM-1411RM and PTM-1411), and anti-L-Lactyl-Histone H4 (Lys16) (PTM BioLab) (1: 1000); anti-H3 (1: 2000), anti-H4 (1: 2000), antiPAX8 (1: 1000), and anti-Lamin B1 (1: 1000) (Abcam); anti-GR (1: 1000), anti-β-actin (1: 2000), and anti-β-Tubulin (1: 2000) (Cell Signaling Technology); anti-PGK1 (1: 1000), anti-VHL (1:1000), antiPKM2 (1: 1000), and anti-LDHA (1: 1000) (ABclonal). .. The agents used were belzutifan and SO (MedChemExpress, MCE), DEX, DCA, sodium lactate, and the Article Title: The immune thrombocytopenia therapeutic Avatrombopag alleviates osteoporosis by targeting NFATc1 signaling. Article Snippet: Osteoporosis is a systemic skeletal disorder characterized by increased osteoclast activity and bone loss, for which the clinical management remains an unmet need.. Here, through in silico drug screening of an FDAapproved drug library, we identified Avatrombopag (Ava) — a thrombopoietin (TPO) receptor agonist approved for immune thrombocytopenia (ITP) — as a potent inhibitor of nuclear factor of activated T cells c1 (NFATc1), the master transcriptional regulator of osteoclastogenesis.. Indeed, Ava significantly inhibited osteoclastogenesis in vitro, with significant inhibitory effects starting at a low concentration. Article Title: Lipid accumulation in foam cells drives C1q-dependent synaptic loss and impairs motor function recovery after spinal cord injury Article Snippet: We first conducted a preliminary screening of compounds from the FDA-approved compound library (Selleck, L1300). .. Our detailed screening criteria are as follows: First, we selected the Article Title: Glucocorticoids elevate clear cell renal cell carcinoma sensitivity to HIF-2α inhibitors by suppressing H4K12 lactylation Article Snippet: The antibodies used were anti- L -Lactyl-Histone H3 (Lys14) (1: 2000), anti- L -Lactyl-Histone H3 (Lys18) (1: 2000), anti- L -Lactyl-Histone H3 (Lys23) (1: 1000), anti- L -Lactyl-Histone H4 (Lys5) (1: 1000), anti- L -Lactyl-Histone H4 (Lys12) (1: 2000) (catalog number: PTM-1411RM and PTM-1411), and anti- L -Lactyl-Histone H4 (Lys16) (PTM BioLab) (1: 1000); anti-H3 (1: 2000), anti-H4 (1: 2000), anti-PAX8 (1: 1000), and anti-Lamin B1 (1: 1000) (Abcam); anti-GR (1: 1000), anti-β-actin (1: 2000), and anti-β-Tubulin (1: 2000) (Cell Signaling Technology); anti-PGK1 (1: 1000), anti-VHL (1:1000), anti-PKM2 (1: 1000), and anti-LDHA (1: 1000) (ABclonal). .. The agents used were belzutifan and SO (MedChemExpress, MCE), DEX, DCA, sodium lactate, and the Article Title: Identification of claramine and anidulafungin as entry inhibitors of Crimean-Congo hemorrhagic fever virus. Article Snippet: .. For small-compound screening, the Article Title: High-throughput screening of small molecule Wnt/β-catenin activators for hair and nail growth. Article Snippet: .. The screening targeted two major libraries: an Article Title: Lipid accumulation in foam cells drives C1q-dependent synaptic loss and impairs motor function recovery after spinal cord injury. Article Snippet: We first conducted a preliminary screening of compounds from the FDA-approved compound library (Selleck, L1300). .. Our detailed screening criteria are as follows: First, we selected the |
![High-content image analysis/dimensionality reduction of drug screening data (A–C) Representative data of high content analysis across six GSC lines and three compound libraries (LOPAC, (A) <t>Prestwick</t> <t>FDA</t> (B) and C3L, (C) by 3D principal component analysis (PCA) (median aggregation to well level, n = 6 fields of view). DMSO controls circled in Black ( n = 48 per plate). Magnitude of vector co-ordinates for PC1, 2, 3 (sized by PC4) are indicated by color, red-pink (strong –PC1, –PC2), blue (strong +PC3, –PC2), green (strong +PC1 +PC2), yellow/gray (weaker phenotypes). PC1-4 factor loadings are given (%). Factor loadings are provided in . (D–F) Phenotypic distance of screened compounds (LOPAC, D, Prestwick FDA, E and C3L, F). We employed 20 principal components (>60% explained variance) to compute a phenotypic distance (Euclidean) for each compound. The corresponding p values are plotted against cell survival (normalized z scores, y axis). Legend indicates strength of –log 10 [ p value] distribution (five bins, red = maximal effect, reducing to gray where at = arbitrary threshold). Several example hits are labeled.](https://pub-med-central-images-cdn.bioz.com/pub_med_central_ids_ending_with_7355/pmc13207355/pmc13207355__gr2.jpg)